What is histamine, a mediator that supports the inflammatory process in asthma, secreted by?

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18-08-2022
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What is histamine, a mediator that supports the inflammatory process in asthma, secreted by?

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tripatsingh039 tripatsingh039 · Answer 1 · 2022-09-01T16:50:52+02:00

Histamine, a mediator that supports the inflammatory process in asthma, is secreted by Mast cells.

The inflammation linked to asthma is largely mediated by mast cells, neutrophils, eosinophils, and lymphocytes. Mast cells emit a number of substances known as mediators when they are activated. One of these substances is histamine. The pathophysiology of asthma has been linked to histamine for the first time.

Mast cells and basophils in the airways produce and release histamine. Vagal cholinergic reflexes play a role in the bronchoconstriction and mucus secretion that histamine produces. For a very long period, histamine—a well-known chemical mediator released by mast cells in acute allergic reactions—was believed to play a significant role in the pathophysiology of asthma.

Learn more about Mast cells here:

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