What was the significance of the Marbury v. Madison case that was argued before the Supreme Court in 1803?
A:This was the first time that the Supreme Court had declared an act of Congress unconstitutional.

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John Adams lost his bid for reelection to Thomas Jefferson in the 1800 Presidential election. Adams was a member of the Federalist party, while Jefferson was a member of the Democratic-Republican party that considered themselves anti-Federalist in their thinking

The significance of the Marbury v. Madison case was that It established that the Supreme Court could declare acts of Congress unconstitutional.