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What effect did the introduction of smallpox have in the Americas?

PLEASE HELP ME BRAINLIEST WILL BE GIVEN 10 PTSWhat effect did the introduction of smallpox have in the Americas class=

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The correct answer is the first option. American Indians had no natural resistance to smallpox, which meant that smallpox killed many of them. This weakened the Natives' armies and indirectly lead to their defeat by the Europeans.