Answer: B. Isolation from the world.
Explanation: In the given excerpt from "Frankenstein" by Mary Shelley, we can see the speaker is resisting to complete his labours of creating a monster, he is doing that by locking the door and going to his apartment alone, with no one to speak with, we can see that in the lines "I was alone; none were near me to dissipate the gloom, and relieve me from the sickening oppression of the most terrible reveries", we can conclude that the topic of this passage is the isolation from the world.
