Base pairing rules have a relation to Chargaff's rule because they both state how the bases pair with each other. Chargaff's rule means it has the same amount or number of purine and pyrimidine bases in DNA. It makes the base pairs more stable structurally when the hydrogen bonds form. Base pairing rule means that the purine adenine (A) always pairs with the pyrimidine thymine (T), and the pyrimidine cytosine (C) always pair with the purine guanine (G) this base pair relationship is observed by the scientist who named after the observation of Chargaff's rule, he knew that there are equal moral concentration of A and T, as well as G & C in DNA molecules.
