The immune system has receptors that can sense flagella from Bacteria but not flagella from Eukaryotic parasites. Propose a reason why this is possible, based on the proteins that form the flagellum.

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16-12-2022
Biology

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The immune system has receptors that can sense flagella from Bacteria but not flagella from Eukaryotic parasites. Propose a reason why this is possible, based on the proteins that form the flagellum.

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contexto1220 contexto1220 · Answer 1 · 2022-12-19T21:03:30+01:00

The TLR5 ligand is flagellin, a major component of bacterial flagella and a structure involved in motility in various bacterial species.

The innate immune system uses various receptors to recognize and respond to pathogens. Those that directly recognize pathogen surfaces often bind to repetitive patterns such as carbohydrate and lipid moieties that are characteristic of microbial surfaces but not found in host cells.

Flagella are primarily motile organelles, allowing movement and chemotaxis. Bacteria can have one or more flagella and are either polar (one or more flagella at one site) or peririch (multiple flagella throughout the bacterium).