A nonsense mutation occurs in DNA when a sequence change results in a stop codon rather than an amino acid-specific codon.
A nonsense mutation is a DNA sequence mutation that results in a shorter, unfinished protein product. DNA is made up of many smaller molecules known as nucleotides. DNA (or RNA) nucleotide sequences are read three nucleotides at a time in units called codons during protein formation, and each codon corresponds to a specific amino acid or stop signal.
Because they do not code for an amino acid and instead signal the end of protein synthesis, stop codons are also known as nonsense codons. When a premature nonsense or stop codon is introduced into the DNA sequence, nonsense mutations occur.
When the mutated sequence is translated into a protein, the result is an incomplete and shorter protein than normal.As a result, the majority of nonsense mutations result in nonfunctional proteins.
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