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Combination drug therapy is less likely to lead to resistance in HIV than single drug therapy because extremely little chance exists that a virus will spontaneously change and develop simultaneous resistance to a number of different medications.
Combination drug therapy is the administration of two or more pharmacologic drugs, either alone or in a fixed-dose combination of two or more active components.
Combination drug therapy is justified by the idea that using medications with various modes of action may reduce the likelihood that cancer cells will become resistant to treatment. When medications with various effects are taken together, each medication can be taken at its ideal dosage without experiencing unpleasant side effects.
Combination drug therapy is commonly used to treat tuberculosis [1]. After the discovery of streptomycin in 1944, the addition of isoniazid, the first oral mycobactericidal medication, in 1952, and rifamycins in 1957 led to an improvement in the efficacy of therapy.
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