The lethal allele is often detected as a distortion in segregation ratios, where one class of expected progeny is missing.
When researching the inheritance of mouse coat color in 1905, Lucien Cuénot made the first discovery of lethal alleles. The majority of mice's coat color is controlled by the agouti gene. Each mouse hair with the wild-type allele has a mixture of black and yellow pigmentation. This mixture of black and yellow is sometimes referred to as "agouti" due to its hue. [3] Mice with one of the mutant alleles of the agouti gene have a much paler, yellowish hue. These yellow mice were crossed with homozygous wild-type mice to produce offspring that were 1:1 mixtures of yellow and dark grey. All of the parental yellow mice were heterozygous for the mutant allele, proving that the yellow mutation is dominant.
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