In beta thalassemia, hemoglobin A levels are lower.
Hb A2 and Hb F levels are elevated in patients with -thalassemia major (although Hb F may be normal in some individuals). If -globin production is moderately hampered, the disease is known as -thalassemia intermedia (β0/β or β+/β+). These people have a less severe disease than those who have -thalassemia major.
A lack of beta-globin results in less functional hemoglobin. Red blood cells do not develop normally in the absence of sufficient hemoglobin, resulting in a shortage of mature red blood cells. In people with beta thalassemia, a lack of mature red blood cells causes anemia and other health problems.
In beta thalassemia, hemoglobin A levels are lower.
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