The release of endogenous pyrogen (or interleukin- 1) by active macrophages would:_____.

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16-08-2022
Biology

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The release of endogenous pyrogen (or interleukin- 1) by active macrophages would:_____.

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rafikiedu07 rafikiedu07 · Answer 1 · 2022-08-20T19:05:43+02:00

The release of endogenous pyrogen (or interleukin- 1) by active macrophages would produce a fever.

Endogenous pyrogens are substances, which originate inside the body and which are capable of inducing fever by acting on the hypothalamic thermoregulatory centre.

IL-1, tumour necrosis factor (TNF) and interferon (INF) are endogenous of albumin and transferrin decreases. Characteristically there are a decreased concentration of iron and zinc and an increased copper concentration.

The low iron is the result of reduced intestinal assimilation of iron and increased liver storage of iron. These changes contribute to host defence by depriving invading micro-organisms of essential nutrients, such as iron and zinc. The process is referred to as nutritional immunity.

The induction of fever results in inhibition of bacterial growth, increased bactericidal effects of neutrophils, production of acute-phase protein synthesis and other physiological changes such as anorexia and somnolence.

These changes suggest that fever has an adaptive role in the host’s survival during infection.

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