Incas were isolated in the "new world" and didn't
have contact with the other cultures around the world like Asians, Europeans
and Africans. For example, the Chinese are the ones who invented gun powder and
the idea spread throughout the rest of the world and was eventually used to
propel ammunition (guns).
The isolation also made Incas susceptible to European
diseases which they had never been exposed to. A large percentage of those
populations died and were weakened before the fighting even began. They also didn’t
have horses or most common beasts of burden because they simply didn’t exist in
South America. The Incas were one of the most powerful empires in their
respective regions and like most empires, they had their share of enemies. Hernán Cortés formed allies with
neighboring tribes which played a huge role in defeating the Aztecs, Francisco Pizarro
did the same in South America.