Hemophilia is a recessive sex-linked disorder (Xh). A man with hemophilia and a female carrier are concerned about their daughter inheriting the disorder. Use a punnett square explain to these parents the probability (percent chance) that their daughter could have the disorder.

Since hemophilia is a disease with a sex-linked recessive inheritance pattern —X chromosome— all males who acquire the altered gene will have hemophilia ([tex]X^{h}[/tex]Y), while a female should have both altered chromosomes ([tex]X^{h}[/tex]X) to manifest the disease.

If a hemophilic male and a female carrier of the hemophilia gene have children, the possibility of having a daughter with hemophilia can be seen by crossing.

♂ [tex]X^{h}[/tex]Y
♀ [tex]X^{h}[/tex]X

Alleles [tex]X^{h}[/tex] Y

[tex]X^{h}[/tex] [tex]X^{h}[/tex][tex]X^{h}[/tex] [tex]X^{h}[/tex]Y

X [tex]X^{h}[/tex]X XY

In the offspring, there are:

Healthy sons 25%.
Hemophilic sons 25%.
Carrier daughters 25%.
Hemophilic daughters 25%.

The hemophilic man and the carrier woman should know that they have a 25% chance of having a hemophilic daughter, or that 50% of their daughters may have the disease.

Hemophilia is a recessive sex-linked disorder (Xh). A man with hemophilia and a female carrier are concerned about their daughter inheriting the disorder. Use a punnett square explain to these parents the probability (percent chance) that their daughter could have the disorder. ​

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Hemophilia is a recessive sex-linked disorder (Xh). A man with hemophilia and a female carrier are concerned about their daughter inheriting the disorder. Use a punnett square explain to these parents the probability (percent chance) that their daughter could have the disorder.