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The effects of LSD are unpredictable. They depend on the amount taken, the person’s mood and personality, and the surroundings in which the drug is used.
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Normally, the first effects of LSD are experienced thirty to ninety minutes after taking the drug. Often, the pupils become dilated. The body temperature can become higher or lower, while the blood pressure and heart rate either increase or decrease. Sweating or chills are not uncommon.

LSD users often experience loss of appetite, sleeplessness, dry mouth and tremors. Visual changes are among the more common effects—the user can become fixated on the intensity of certain colors.